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pentobarbital decreases amounts of toremifene by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep track of. CYP3A4 inducers improve rate of toremifene metabolism, decreasing the steady-state concentration in serum.pentobarbital will lower the extent or influence of eplerenone by impacting hepatic/intestinal enzyme CYP3A4 meta